Keller & Miller (K&M) assert that mental disorders could not have evolved as adaptations, but they fail to make their case against the theory of the evolutionary origin of bipolar disorder that I have proposed (Sherman 2001). Such an idea may be unorthodox, but it has considerable explanatory power and heuristic value. (Published Online November 9 2006).

Spatial visualization as a key variable in sex-related differences in mathematical problem solving and spatial aspects of geometry is traced to the 1960s. More recent relevant data are presented. The variability debate is traced to the latter part of the nineteenth century and an explanation for it is suggested. An idea is presented for further research to clarify sex-related brain laterality differences in solving spatial problems.

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In an increasingly interconnected global community, severe disasters or disease outbreaks in one country or region may rapidly impact global health security. As seen during the responses to the earthquakes in Haiti and Japan, Typhoon Haiyan in the Philippines, and the current Ebola outbreak in West Africa, local response capacities can be rapidly overwhelmed and international assistance may be necessary to support the affected region to respond and recover and to protect other countries from the spread of disease. For example, (...) President Obama stated on September 16, 2014, that “if the [Ebola] outbreak is not stopped now, we could be looking at hundreds of thousands of people infected, with profound political and economic and security implications for all of us…. [T]his…is not just a threat to regional security — it’s a potential threat to global security if these countries break down…. And that’s why…I directed my team to make this a national security priority.”. (shrink)

Julia Annas has written a monumental work that is in the best sense of the word, a “conversation” with ancient theories of morality. Indeed what we have in the Morality of Happiness is a sustained conversation with the various ancient schools on the nature of eudaimonia and the moral dimensions of the best life for humans. This is a work that takes the Hellenists seriously, and as such, gives us both a fresh way of assessing Aristotle in terms of (...) the refinements that were to come later, as well as insights about the Hellenist foundation of many of our modern formulations. But the trajectory into modern morality is not Annas’ primary aim. On the whole, for the duration of this book, we are immersed in the debate between the various schools themselves and in the richness of their own dialogue. To be sure, there are lessons to be learned for ourselves and our own way of doing moral theory. But these stand out primarily from the contrasts. So for example, Plato’s Protagoras aside, Annas argues that notions of maximization and algorithmic procedures for arriving at right action are not to be found in ancient theory. A “problem-solving mechanism” for hard cases is simply not the ancient preoccupation, despite the fact that conflicts abound in the ancient world no less than in the modern era. (shrink)

The present study evaluated the relationship between job satisfaction and unethical pro-organizational behavior (UPB), directly as well as indirectly, through organizational commitment. Multidimensional constructs were utilized for job satisfaction and organizational commitment to provide a granular understanding of how these constructs can motivate employees to engage in UPB, which can threaten organizations' success and diminish the public's confidence in organizations. In order to test these relationships, a diverse sample of 617 participants was recruited through the online survey distribution platform Amazon (...) Mechanical Turk (MTurk®) to test the theoretical model using structural equation modeling (SEM). The results indicated that identification, affiliation, and exchange commitment served as intervening variables between growth satisfaction and UPB, while no significant indirect effect of internal work motivation on UPB was found. Implications for research and practice are discussed. (shrink)

The present study evaluated the relationship between job satisfaction and unethical pro-organizational behavior, directly as well as indirectly, through organizational commitment. Multidimensional constructs were utilized for job satisfaction and organizational commitment to provide a granular understanding of how these constructs can motivate employees to engage in UPB, which can threaten organizations' success and diminish the public's confidence in organizations. In order to test these relationships, a diverse sample of 617 participants was recruited through the online survey distribution platform Amazon Mechanical (...) Turk to test the theoretical model using structural equation modeling. The results indicated that identification, affiliation, and exchange commitment served as intervening variables between growth satisfaction and UPB, while no significant indirect effect of internal work motivation on UPB was found. Implications for research and practice are discussed. (shrink)

German theologian F. D. E. Schleiermacher's doctrine of God-the first to be developed in the post-Kantian era-fundamentally changed the course of Christian theology. The degree to which his doctrine of God was influenced by the philosophy of Benedict de Spinoza remains in dispute, however. This study examines the ways in which Schleiermacher actively adopted elements of Spinoza's thought in the development of his own theological doctrine of God. Julia Lamm's analysis of little-known but seminal essays by Schleiermacher reveals his (...) young creative genius in daring to go beyond the neo-Spinozism of Herder and the post-Kantianism of Fichte by developing his own post-Kantian Spinozism. Schleiermacher's unique simultaneous appropriation of Kant and Spinoza is characterized by four themes: an organic monism, an ethical determinism, a critical realism, and a nonanthropomorphic view of God, which Lamm traces through his two major theological works, On Religion: Speeches to Its Cultured Despisers and The Christian Faith. Ultimately, Lamm finds that Schleiermacher departs from Spinoza in significant ways. Most notably, he talks about "the living God" who is best expressed through the divine attributes of love and wisdom. This living God is what Schleiermacher refers to as the "third alternative" to, on the one hand, the anthropomorphized God of orthodox Protestantism and, on the other hand, Spinoza's natura naturans. (shrink)

This article analyses supplier–buyer relationships where the suppliers adapt to the buyers’ needs and expectations to gain mutual advantages. In some cases, such closely knit relationships lead to violations of the autonomy of one or both partners. A concept of corporate autonomy is developed to analyze this problem. Three different facets can be distinguished: rule autonomy, executive autonomy, and control autonomy. A case study of Mattel’s problems with lead-contaminated toys produced in China shows that the CA of buyer and supplier (...) can be restricted as a result of a dysfunctional partnership involving a moral dilemma. (shrink)

The aim of the study was to develop a new comprehensive reading assessment battery for multi-ethnic and multilingual learners in Malaysia. Using this assessment battery, we examined the reliability, validity, and dimensionality of the factors associated with reading difficulties/disabilities in the Malay language, a highly transparent alphabetic orthography. In order to further evaluate the reading assessment battery, we compared results from the assessment battery with those obtained from the Malaysian national screening instrument. In the study, 866 Grade 1 children from (...) multi-ethnic and multilingual backgrounds from 11 government primary schools participated. The reading assessment battery comprised 13 assessments, namely, reading comprehension, spelling, listening comprehension, letter name knowledge, letter name fluency, rapid automatized naming, word reading accuracy, word reading efficiency, oral reading fluency, expressive vocabulary, receptive vocabulary, elision, and phonological memory. High reliability and validity were found for the assessments. An exploratory factor analysis yielded three main constructs: phonological-decoding, sublexical-fluency, and vocabulary-memory. Phonological-decoding was found to be the most reliable construct that distinguished between at-risk and non-at-risk children. Identifying these underlying factors will be useful for detecting children at-risk for developing reading difficulties in the Malay language. In addition, these results highlight the importance of including a range of reading and reading-related measures for the early diagnosis of reading difficulties in this highly transparent orthography. (shrink)

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises (...) a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus. (shrink)

German theologian F. D. E. Schleiermacher's doctrine of God-the first to be developed in the post-Kantian era-fundamentally changed the course of Christian theology. The degree to which his doctrine of God was influenced by the philosophy of Benedict de Spinoza remains in dispute, however. This study examines the ways in which Schleiermacher actively adopted elements of Spinoza's thought in the development of his own theological doctrine of God. Julia Lamm's analysis of little-known but seminal essays by Schleiermacher reveals his (...) young creative genius in daring to go beyond the neo-Spinozism of Herder and the post-Kantianism of Fichte by developing his own post-Kantian Spinozism. Schleiermacher's unique simultaneous appropriation of Kant and Spinoza is characterized by four themes: an organic monism, an ethical determinism, a critical realism, and a nonanthropomorphic view of God, which Lamm traces through his two major theological works, On Religion: Speeches to Its Cultured Despisers and The Christian Faith. Ultimately, Lamm finds that Schleiermacher departs from Spinoza in significant ways. Most notably, he talks about "the living God" who is best expressed through the divine attributes of love and wisdom. This living God is what Schleiermacher refers to as the "third alternative" to, on the one hand, the anthropomorphized God of orthodox Protestantism and, on the other hand, Spinoza's natura naturans. (shrink)

Zusammenfassung Sprechen Wissenschaftler üblicherweise vom Platonischen Charakter der Dialektik Schleiermachers, meinen sie deren grundlegend Sokratisch-dialogischen Charakter, zumal Schleiermacher Dialektik als „die Kunst des Diskurses oder des Dialogs“ definierte. Problematisch daran ist nun, daß Platons Dialoge mehr als eine Art von Dialektik aufweisen. Der Aufsatz beginnt mit einem Überblick auf die, in der „Allgemeinen Einleitung“ dargelegten fünf Grunddeutungsprinzipien, die Schleiermachers Interpretation der platonischen Dialektik untermauern, leiten und einschränken sollen. Der Beitrag wendet sich dann den Einleitungen der einzelnen Dialoge zu, um zu (...) überprüfen, wie Schleiermacher diese Prinzipien auf konkrete Situationen bei seiner Bearbeitung eines jeden Dialogs anwendet. Schleiermacher scheint manchmal einfach die eher spekulativen Züge der Platonischen Dialektik zu ignorieren, wie seine Interpretation des Phaidros zeigt. Gelingt es ihm nicht diese spekulativen Züge zu ignorieren, unterdrückt er sie, indem er einen zwingenden Bezug zur dialogischen Form der Dialektik herstellt, wie seine Interpretationen des Sophistes und des Phaidon zeigen. Läßt er dann schließlich einen bestimmten unabhängigen Status der spekulativen Dialektik Platons zu, marginalisiert Schleiermacher die entsprechenden Passagen so, daß er sie ihrer Bedeutung beraubt, wie seine Interpretation der Bücher V–VII der Politeia zeigt. (shrink)

This article offers an interpretive reconstruction of Heidegger’s first reference to the “inner truth of National Socialism” in the 1934/35 lecture course, Hölderlin’s Hymns “Germania” and “The Rhine”, which has remained unknown due to an editorial error. Focusing on the distinction Heidegger draws between Greek φύσις and natural science, it examines the way Heidegger conceives politics more originally through Hölderlin and the naming force of Nature. It then contextualizes Heidegger’s specific reference to National Socialism in terms of the then contemporary (...) debate between liberalism and the racially determined “new science,” arguing that Heidegger thinks the “inner truth of National Socialism” as a φύσις-event. (shrink)

This article analyses supplier-buyer relationships where the suppliers adapt to the buyers' needs and expectations to gain mutual advantages. In some cases, such closely knit relationships lead to violations of the autonomy of one or both partners. A concept of corporate autonomy (CA) is developed to analyze this problem. Three different facets can be distinguished: rule autonomy, executive autonomy, and control autonomy. A case study of Mattel's problems with lead-contaminated toys produced in China shows that the CA of buyer and (...) supplier can be restricted as a result of a dysfunctional partnership involving a moral dilemma. (shrink)

This paper offers a close analysis of Heidegger’s interpretation of the demigod in his 1934/35 lecture course, Hölderlins Hymnen “Germanien}” und} “Der Rhein}” (Gesamtausgabe 39). Focusing on Hölderlin’s two different versions of Strophe VIII of “The Rhine” hymn, it traces through Heidegger’s inaugural insights into the structure of need (Brauch}) articulated in the “The Rhine” hymn as the gods’ need and use of the demigods to “feel something of themselves.” Contrasting this with Plato’s analysis of the demigod in the Symposium, (...) the paper argues that for Heidegger the between is original in first founding the limit between gods and human beings through the creation of a new kind of otherness. It then goes on to follow out this insight through Heidegger’s interpretation of the counterturning course of the Rhine river in relationship to its origin, asserting that what is at stake in that analysis is Heidegger’s working out of a new conception of creativity realized through the river’s dwelling poetically. (shrink)

The menopause transition is associated with an increased risk of depressed mood. Preliminary evidence suggests that increased sensitivity to psychosocial stress, triggered by exaggerated perimenopausal estradiol fluctuation, may play a role. However, accurately quantifying estradiol fluctuation while minimizing participant burden has posed a methodological challenge in the field. The current pilot project aimed to test the feasibility of capturing perimenopausal estradiol fluctuation via 12 weekly measurements of estrone-3-glucuronide (E1G), a urinary metabolite of estradiol, using participant-collected urine samples in 15 euthymic (...) perimenopausal women ages 45-55 years. Furthermore, it aimed to correlate E1G fluctuation (standard deviation across the 12 E1G measurements) with weekly mood and cardiovascular, salivary cortisol, and subjective emotional responses to the Trier Social Stress Test (TSST) at weeks 4, 8 and 12. Protocol acceptability and adherence was high; furthermore, E1G fluctuation was positively associated with anhedonic depressive symptoms and weekly negative affect. E1G fluctuation was also associated with increased heart rate throughout the TSST as well as higher levels of rejection, anger, and sadness. E1G fluctuation was not significantly associated with TSST blood pressure or cortisol levels. This study suggests a feasible method of assessing estradiol fluctuation in the menopause transition and provides support for the hypothesis that perimenopausal estradiol fluctuation increases sensitivity to psychosocial stress and vulnerability to depressed mood. (shrink)

Online data collection methods are expanding the ease and access of developmental research for researchers and participants alike. While its popularity among developmental scientists has soared during the COVID-19 pandemic, its potential goes beyond just a means for safe, socially distanced data collection. In particular, advances in video conferencing software has enabled researchers to engage in face-to-face interactions with participants from nearly any location at any time. Due to the novelty of these methods, however, many researchers still remain uncertain about (...) the differences in available approaches as well as the validity of online methods more broadly. In this article, we aim to address both issues with a focus on moderated data collected using video-conferencing software. First, we review existing approaches for designing and executing moderated online studies with young children. We also present concrete examples of studies that implemented choice and verbal measures and looking time across both in-person and online moderated data collection methods. Direct comparison of the two methods within each study as well as a meta-analysis of all studies suggest that the results from the two methods are comparable, providing empirical support for the validity of moderated online data collection. Finally, we discuss current limitations of online data collection and possible solutions, as well as its potential to increase the accessibility, diversity, and replicability of developmental science. (shrink)

The Studies in Islamic Philosophy begins with a highly readable, annotated translation of Ghazali's Faysal al Tafriqa. Abu Hamid al Ghazali, one of the most famous Muslim intellectuals in the history of Islam set out to provide a legally sanitized definition of Unbelief as the basis for a criterion for determining who, as far as theology is concerned, is to be considered a Muslim and who is not.

ExcerptIn his insightful book Human Rights as Politics and Idolatry, Michael Ignatieff observes that “[t]he challenge of Islam has been there from the beginning.”1 Ignatieff is not alone among Western observers. And in this context, I would like to begin by stating up front that I am neither an opponent of human rights per se nor among those tradition-bound Muslims—though that I am–who abstain from either endorsing the construct or rejecting it outright, presumably as an exercise of sorts in “passive (...) resistance.” Similarly, I do not believe, as another scholar characterizes the position of revealed religion, that “human rights are a secular usurpation of the rights of God.”2 In fact, as I will show, for well over half a millennium, Muslims have theorized on what could only be considered a concept of human rights, while simultaneously recognizing the “rights of God.” Nor do I believe, contrary to popular perception, that the purportedly “secular” roots of human rights necessarily place them outside the reach of Islam, unless, of course, one assumes, as I do not, that the dominant understanding of “secular” in the West is the only meaning the term can legitimately carry. These are among the reasons why, for me, the idea of summarily rejecting human rights seems so unnecessary if not misguided. (shrink)

Abu Hamid al Ghazali, one of the most famous intellectuals in the history of Islam, developed a definition of Unbelief (kufr) to serve as the basis for determining who, in theological terms, should be considered a Muslim and who should not. Jackson's annotated translation is preceded by an introduction that reconstructs the historical and theoretical context of the Faysal and discusses its relevance for contemporary thought and practice.

Since the 2007 Vick dog-fighting case, much attention has been focused on cruelty against dogs. Cockfighting roosters, on the other hand, have been virtually ignored by scientists and laypeople alike. Accordingly, very little is known about our emotional reactions to roosters used for cockfighting. The present study attempts to fill this void in the scientific literature by examining the relationship between individual differences variables and sympathetic reactions to roosters used for cockfighting depicted in a video newscast. The results were robust, (...) with individual differences variables explaining 51% of the variability in sympathetic reactions to cockfighting roosters. Specifically, feelings toward roosters, extraversion, conscientiousness, and trait sympathy for animal suffering emerged as significant predictors, while belief in animal mind did not. The implications and limitations of these results are discussed. (shrink)

The prevalence of negative representations of Alzheimer’s disease reinforces the stigma and negative attitudes toward this dementia. To mitigate these negative views, campaigns have been launched by several organizations. This study aims to explore the effect of framing in AD campaigns on attitude change. For this purpose, several posters were designed with framed messages defining dementia and 189 participants were shown the posters. In order to analyze the effect of the different frames, a repeated-measures design was used, in which attitudes (...) toward dementia were measured three times. The impact of the campaign and the emotions it produced were recorded as well as the effects of the participants’ experience with AD and the importance they attached to it. Posters with unity-framed messages produced a positive and lasting change in attitudes toward dementia and higher levels of happiness, while dualism-framed messages had a greater impact and produced feelings of sadness, anger, and fear but did not change the audience’s attitude. Although more research is needed on persuasion in campaigns, the findings can serve to guide the design of AD campaigns. (shrink)